Langmuir, Irving, 1881-1957

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Research chemist and physicist, General Electric Co. from 1909. Nobel Prize for Chemistry, 1932.

From the description of Pathological science [sound recording] : an address to General Electric's Knolls Atomic Power Laboratory Colloquium; 1953 December 18. (Unknown). WorldCat record id: 83715356

Chemist.

From the description of Papers of Irving Langmuir, 1871-1957. (Unknown). WorldCat record id: 79449037

Biographical Note

  • 1881, Jan. 31: Born, Brooklyn, N. Y.
  • 1903: B.S, Columbia School of Mines, Columbia University, N.Y.
  • 1906: Ph.D., University of Göttingen, Göttingen, Germany
  • 1906 - 1909 : Chemistry instructor, Stevens Institute, Hoboken, N.J.
  • 1909 - 1950 : Engaged in physical chemistry research, Research Laboratory of General Electric Co., Schenectady, N.Y
  • 1932: Nobel Prize in Chemistry
  • 1950 - 1957 : Consultant to General Electric Research Laboratory
  • 1957, Aug. 16: Died, Falmouth, Mass.

From the guide to the Irving Langmuir Papers, 1871-1957, (Manuscript Division Library of Congress)

Max Bergmann (February 12, 1886-November 7, 1944) was a biochemist, whose research proved key for the study of biochemical processes. His work on peptide synthesis and protein splitting provided a starting point for modern protein chemistry and the study of enzyme-substrate interactions. He is most noted for developing the carbobenzoxy protecting group, for the synthesis of oligopeptides, using any amino acid in any sequence. He co-authored with his colleague Joseph S. Fruton (1912-2007, APS 1967) several reviews in protein and enzyme chemistry, notably “Proteolytic Enzymes,” in the Annual Review of Biochemistry 10 (1941): 31-46 and “The Specificity of Proteinases,” in Advances in Enzymology 1 (1941): 63-98.

Bergmann was born in Fürth, Germany, the son of a coal merchant named Solomon Bergmann and his wife Rosalie Stettauer. He entered the University of Munich, initially interested in botany, but shifted to chemistry, after being convinced that biological questions could only be answered by the methods of organic chemistry. He received a bachelor’s degree in 1907, and afterward became a student of Emil Fischer (1838-1914, APS 1909), the foremost protein and carbohydrate chemist of the day at the University of Berlin. In 1911 Bergmann received a Ph.D. with a dissertation on acyl polysulfides and became Fischer’s research assistant. In 1912 Bergmann married Emmy Miriam Grunwald with whom he had two children. The marriage ended in divorce, and he remarried Martha Suter in 1926. During World War I Bergmann was exempted from military service because of his research work with Fischer. While working with Fischer, Bergmann made important contributions to carbohydrate, lipid, tannin and amino acid chemistry, developing new methods for the preparation of α-monoglycerides. In 1920 Bergmann was appointed Privatdozent at the University of Berlin and head of the chemistry department at the Kaiser Wilhelm Institute for Textile Research.

Bergmann left the University of Berlin in 1921 to become the director of the new Kaiser Wilhelm Institute for Leather Research and Professor of chemistry at the Dresden Technical University. At Dresden, Bergmann created one of the world’s leading laboratories for the study of protein chemistry. After Adolf Hitler’s rise to power, Bergmann, a Jew, emigrated to the United States. From 1934 until his death Bergmann was affiliated with the Rockefeller Institute for Medical Research in New York.

Bergmann represents the tradition of German organic chemistry applied to biological problems. Working with his mentor Fischer, who sought effective methods to separate and identify amino acids, and who identified the peptide bond as the structure that connects amino acids, Bergmann made many basic contributions to protein and amino acid chemistry. In Dresden he extended Fischer’s work of separating and identifying the amino acid constituents of proteins. In order to establish the conjecture of some protein chemists that proteins were, in fact, polypeptides, containing thousands of amino acids, Bergmann developed new methods of peptide synthesis. The most important discovery came in 1932, when he and his colleague Leonidas Zervas created the carbobenzoxy method allowing them to use any amino acid in any sequence to produce peptides and polypeptides that closely resembled naturally occurring proteins.

Bergmann continued this work in New York at the Rockefeller Institute, stressing two new lines of research: (1) expanding the carbobenzoxy method to form peptides that could serve as substrates for protein-splitting enzymes, and (2) unraveling the total structure of proteins. After becoming head of the chemistry laboratory at the Rockefeller Institute in 1937, Bergmann recruited several talented biochemists. Along with his colleague Joseph Fruton, he discovered the first synthetic peptide substrates for which several enzymes were catalysts. When they demonstrated that the enzyme pepsin was able to catalyze the hydrolysis of synthetic peptides, they implicated the peptide bond in protein structure, but also provided the first clear evidence that specific enzymes split peptides at exact linkages in the chain. Their discovery cleared the path for study of how enzymes act as catalysts for every biological function.

Bergmann’s methods of analysis and synthesis proved incapable of solving the riddle of protein structure. He applied methods for separation and quantitative analysis to every amino acid in a protein in an attempt to establish their sequence in the polypeptide chain. In 1938 he proposed a theory of the systematic recurrence in the location of every amino acid residue in the peptide chain of a protein. However, his hypothesis proved an oversimplification. Two biochemists in his working group, Standford Moore and William Stein, showed him that the analytical data did not support his “periodic theory,” and Bergmann was forced to abandon it. Moore and Stein later collaborated in developing novel methods for quantitative analysis of amino acids in protein hydrolysates, methods they perfected after World War II. By 1949 it was possible to determine the order of the links of each amino acid in a protein. The Englishman Frederick Sanger was the first to establish the complete amino acid sequence in a protein, the hormone insulin. Moore and Stein followed by identifying the sequence of a more complex protein, the enzyme ribonuclease.

Bergman died of cancer in New York City on November 7, 1944. His mastery of peptide synthesis and protein splitting constituted the beginnings of modern protein chemistry. Bringing to the United States a background in German organic chemistry, he laid the foundations for the work of others, who would fulfill Bergmann’s goal of understanding and mapping the molecular structure of proteins and enzymes. His research colleagues found him a supportive leader and collaborator. He coauthored a number of publications with other members of his research group.

From the guide to the Max Bergmann papers, [ca. 1930]-1945, 1930-1945, (American Philosophical Society)

Archival Resources
Role Title Holding Repository
referencedIn Hottel, Hoyt C., 1903-2000. Oral history interview with Hoyt C. Hottel 1985 November 18 and December 2 Chemical Heritage Foundation, Othmer Library of Chemical History
referencedIn Hammond, John Hays, 1888-1965. John Hays Hammond papers, 1908-1965 (bulk 1912-1953). Library of Congress
creatorOf Kaufman, Enit, 1908?-1961. American Portraits Papers, 1914-1958 (bulk 1940-1944). Harry Ransom Humanities Research Center
creatorOf General Electric Company. Correspondence with Theodore Dreiser, 1935-1936. University of Pennsylvania Libraries, Van Pelt Library
referencedIn Wrinch, Dorothy, 1894-1976. Dorothy Wrinch Papers, 1919-1975. Smith College, Neilson Library
referencedIn Archive for the History of Quantum Physics, 1898-1950 (bulk), 1898-1950 American Philosophical Society
referencedIn Hildebrand, Joel Henry, 1881-. Oral history interview with Joel Henry Hildebrand,, 1962 August 6. American Institute of Physics, Niels Bohr Library
referencedIn General Electric Company. General Electric photograph collection, 1890-1960. American Institute of Physics, Niels Bohr Library
creatorOf Irving Langmuir Papers, 1871-1957 Manuscript Division, Library of Congress
referencedIn Mott-Smith, Harold Meade, 1897-. Oral history interview with H. M. Mott-Smith, 1977 March 1 and 2. American Institute of Physics, Niels Bohr Library
referencedIn John Archibald Wheeler Papers, 1880-2008, 1880-2008 American Philosophical Society
referencedIn Thomas Foxen Anderson Papers, 1928-1989 American Philosophical Society
creatorOf Trow, Waldo Duane. Correspondence with Irving Langmuir, Arthur A. Noyes, and Walter C. Schumb, 1930. University of Pennsylvania Libraries, Van Pelt Library
creatorOf Langmuir, Irving, 1881-1957. Irving Langmuir correspondence : mss., 1914-1921. UC Berkeley Libraries
referencedIn Enit Kaufman, American Portraits, Papers, TXRC99-A1., 1914-1958 Harry Ransom Humanities Research Center
referencedIn Loeb, Leonard B. (Leonard Benedict), 1891-. Oral history interview with Leonard B. Loeb, 1962 August 7. American Institute of Physics, Niels Bohr Library
referencedIn General Electric Company. Selected records, including letters, reports, and notebooks by Arthur Holly Compton, Saul Dushman, Irving Langmuir, Frederic Saunders, and Willis R. Whitney. American Institute of Physics, Niels Bohr Library
referencedIn Hammett, Louis P. (Louis Plack), 1894-1987. Oral history interview with Louis Plack Hammett, 1978 May 1 and 22. American Institute of Physics, Niels Bohr Library
creatorOf Langmuir, Irving, 1881-1957. Pathological science [sound recording] : an address to General Electric's Knolls Atomic Power Laboratory Colloquium; 1953 December 18. American Institute of Physics, Niels Bohr Library
referencedIn Bohr, Niels, 1885-1962. Bohr scientific correspondence, supplement, 1910-1962. American Institute of Physics, Niels Bohr Library
referencedIn Bohr, Niels, 1885-1962. Manuscripts, other authors, 1910-1961. American Institute of Physics, Niels Bohr Library
creatorOf Langmuir, Irving, 1881-1957. Letter, 1929-1932. University of Pennsylvania Libraries, Van Pelt Library
referencedIn John Hays Hammond Papers, 1908-1965, (bulk 1912-1953) Manuscript Division, Library of Congress
referencedIn Miscellaneous Manuscripts Collection, 1668-1983, Bulk, 1750-1850, 1668-1983 American Philosophical Society
referencedIn Vonnegut, Bernard. Bernard Vonnegut papers, 1936-1997. University at Albany, University Libraries
referencedIn Born, Max, 1882-1970. Journey to Russia, 1945. American Institute of Physics, Niels Bohr Library
referencedIn Letters to John Torrence Tate, 1928. American Institute of Physics, Niels Bohr Library
referencedIn Bergmann, M. (Max), 1886-1944. Papers, [ca. 1930]-1945. American Philosophical Society Library
referencedIn Hans Bethe papers, [ca. 1931]-1995 Division of Rare and Manuscript Collections, Cornell University Library.
referencedIn Elihu Thomson Papers, 1865-1944 American Philosophical Society
creatorOf Langmuir, Irving, 1881-1957. Papers of Irving Langmuir, 1871-1957. Library of Congress
referencedIn Pauling, Linus, 1901-1994. Oral history interview with Linus Carl Pauling, 1964 March 27. American Institute of Physics, Niels Bohr Library
referencedIn McGinn, Robert E., 1941-,. Interview conducted by Oliver Daniel, July 30, 1979 [sound recording]. University of Pennsylvania Libraries, Van Pelt Library
referencedIn Dorothy Wrinch Papers MS 178., 1901-1983, 1919-1975 Sophia Smith Collection
referencedIn Leverenz, Humboldt Walter, 1909-. Oral history interview with Humboldt Walter Leverenz, 1979 July 10. American Institute of Physics, Niels Bohr Library
creatorOf Max Bergmann papers, [ca. 1930]-1945, 1930-1945 American Philosophical Society
referencedIn Bethe, Hans A. (Hans Albrecht), 1906-2005. Hans Bethe papers, [ca. 1931]-1992. Cornell University Library
referencedIn Thomson, Elihu, 1853-1937. Papers, 1853-1955. American Philosophical Society Library
referencedIn Department of Chemistry papers, 1880-1980 University of Minnesota Libraries. University Archives [uarc]
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correspondedWith Bush, Vannevar, 1890-1974 person
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correspondedWith Stokowski, Leopold, 1882-1977 person
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associatedWith Thomson, J. J., Sir, (Joseph John), 1856-1940 person
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correspondedWith Whitney, Willis Rodney, 1868-1958 person
correspondedWith Wrinch, Dorothy, 1894-1976 person
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Place Name Admin Code Country
George, Lake (N.Y. : Lake)
George, Lake (N.Y. : Lake)
United States
Germany--Göttingen
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Chemistry--United States
Military research
Science--Societies, etc
Welding
Atomic hydrogen
Smoke screens
Universities and colleges
Scientists, Refugee
Water temperature--New York (State)--George, Lake (Lake)
Chemistry, Physical and theoretical
Scientists--United States
Jewish scientists
Snowpack augmentation
Incandescent gas-lighting
Biochemistry--United States
Weather control
Radio
Vacuum-tubes
Bathythermograph
Precipitation (Meteorology)--Modification
Incandescent lamps
Electric lamps
World War, 1939-1945--United States
Political refugees
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Chemists
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Birth 1881-01-31

Death 1957-08-16

Americans

English

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