Oral history interview with David Baltimore, 1994 February 7, 1995 April 13, 1995 April 29

ArchivalResource

Baltimore, David, 1920-. Oral history interview with David Baltimore, 1994 February 7, 1995 April 13, 1995 April 29

Oral history interview with David Baltimore, 1994 February 7, 1995 April 13, 1995 April 29

David Baltimore begins the series of interviews describing his interest in biology as a high-school student and throughout his college years at Swarthmore. During college he spent a summer at Cold Spring Harbor where he met Cy Levinthal and Salva Luria, both of whom encouraged him to go to graduate school at MIT. As an undergraduate, Baltimore held an interest in viruses. Knowledge and study of animal virology were still very limited, and when he decided to devote his Ph.D. thesis to this topic, he moved to Rockefeller University to join Richard M. Franklin who was working with mengovirus. In his graduate work, he discovered that cultured animal cells infected with mengovirus synthesized an enzyme that catalyzed the synthesis of viral RNA. This was the first example of a virus coding for an RNA-dependent RNA polymerase. He then began working with poliovirus, work that continued for many years. In 1965 Renato Dulbecco asked Baltimore to join him at the Salk Institute for Biological Studies. There he initially focused on the replication of poliovirus RNA. With Mike Jacobson, a graduate student, he also began studying viral protein synthesis. Their work contributed to the recognition of the importance of proteolytic processing in the synthesis of eukaryotic proteins. Baltimore left the Salk Institute after two and a half years and returned to MIT in 1968 as an Associate Professor of Microbiology. He continued to focus his research on poliovirus, but also began work on vesicular stomatitis virus [VSV]. He and his wife, Alice Huang, who at the time was a research associate in his lab, discovered that VSV carried an RNA-dependent RNA polymerase within the virus particle. This work provided the insight that led to his discovery of reverse transcriptase -- the enzyme in retroviruses that transcribes DNA from RNA -- and won Baltimore the Nobel Prize for Physiology or Medicine in 1975 along with Howard Temin and Renato Dulbecco. Baltimore's work with retroviruses was the beginning of his interest in and work on cancer and tumor biology. In the mid-1970s, Baltimore expanded his research interests into the field of immunology, specifically into the areas of B cell development and antibody diversity. Baltimore concludes the interviews with a discussion of the discovery of reverse transcriptase, and thoughts on his research on poliovirus, retroviruses and immunology at MIT in the 1980s.

Sound recordings ; cassettesTranscript : (108 leaves) ; 29 cm.

Related Entities

There are 10 Entities related to this resource.

Massachusetts Institute of Technology

http://n2t.net/ark:/99166/w6sv8d0k (corporateBody)

The Department of General Studies at the Massachusetts Institute of Technology (MIT) did not officially exist until 1882. Courses in general studies were offered as early as 1865, when the MIT Catalog offered a curriculum option called the Course in Science and Literature. At that time, all regular MIT students were required to take “general studies” classes from the Course in Science and Literature, in addition to English, history, and modern languages. In 1882 the Course in Scienc...

Rockefeller Institute for Medical Research.

http://n2t.net/ark:/99166/w62n8x6w (corporateBody)

The Rockefeller Institute for Medical Research was established in 1901. It was the first institution in the United States devoted solely to bio-medical research. In 1958 the name was changed to the Rockefeller Institute; in 1965 the Institute became the Rockefeller University. From the description of Meningitis records, [ca. 1907-1911]. (American Philosophical Society Library). WorldCat record id: 122523442 The Rockefeller Institute for Medical Research was founded in 1901 i...

Schlesinger, Sondra

http://n2t.net/ark:/99166/w64q8tgj (person)

Whitehead Institute for Biomedical Research

http://n2t.net/ark:/99166/w6j43r3r (corporateBody)

Albert Einstein College of Medicine

http://n2t.net/ark:/99166/w6j14vg8 (corporateBody)

American cancer society

http://n2t.net/ark:/99166/w6vm81zs (corporateBody)

Salk Institute for Biological Studies

http://n2t.net/ark:/99166/w64f6gjs (corporateBody)

Chemical Heritage Foundation.

http://n2t.net/ark:/99166/w6jq5h3g (corporateBody)

California institute of technology

http://n2t.net/ark:/99166/w6rj8cxv (corporateBody)

Baltimore, David, 1938-

http://n2t.net/ark:/99166/w6w66x1v (person)

Born in New York City, New York on 7 March 1938. Education: B.A., Chemistry, Swarthmore College (1960) ; Ph.D., Rockefeller University (1964). Employment: 1964-1965 Albert Einstein College of Medicine ; 1965-1968 The Salk Institute for Biological Studies ; 1982-1990 Whitehead Institute for Biomedical Research ; 1990-1994 The Rockefeller University ; 1973-1983, 1994-1997 American Cancer Society ; 1963-1964, 1968-1990, 1994-1997 Massachusetts Institute of Technology ; 1997- California Institute of...