An Episcopalian turned Baptist, Hooper was a Theological professor at Furman Institute, South Carolina, 1838-40; professor at South Carolina College, 1840-46; President of Wake Forest College, 1846-49; teacher in a classical school near Littleton, North Carolina, 1849-51; pastor of New Bern Baptist Church, 1852-54; President of Chowan Female Collegiate Institute, Murfreesboro, North Carolina, 1855-61; teacher in the Female Seminary, Fayetteville, North Carolina, 1861-65; and associate principal with his son-in-law, John D. Hooper of Wilson Collegiate Seminary for Young Ladies, 1866-76; He moved to Chapel Hill, North Carolina where he died Aug. 19, 1876.
From the description of William Hooper Papers, 1823-1980 (Wake Forest University - ZSR Library). WorldCat record id: 60690705