Born Margarethe Meseritz in Berlin on September 18, 1891, Muehsam studied law and then worked as a journalist. She was married to John Edelheim from 1918 until his death in 1931, and was active in journalism, politics and Jewish affairs. She emigrated to the United States in 1938, where she continued her journalistic activities. She married Eduard Muehsam in 1946. She was a member of the board of directors of the Leo Baeck Institute, and died in New York City on May 26, 1975.
From the guide to the Margarete Muehsam Collection, 1913-1975, (Leo Baeck Institute Archives)