Demerec, M. (Milislav), 1895-1966

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Milislav Demerec, who immigrated from Yugoslavia in 1919, worked as a geneticist at the Cold Spring Harbor Laboratory in New York from 1923-1960. His major work was in maize genetics, on Drosophila virilis, and radiation and chemical mutagens.

From the description of Papers, 1919-1966. (American Philosophical Society Library). WorldCat record id: 122464703

Papers of James V. Neel, pioneering human population geneticist and professor in the Department of Human Genetics, University of Michigan Medical School. Curt Stern's first graduate student at the University of Rochester, and a post-doctoral student under Theodosius Dobzhansky, Neel began his career as a Drosophila geneticist, but after taking his first professional appointment as an assistant professor at Dartmouth, decided to alter his course into human genetics. Reasoning that he needed a solid medical education to complement his genetical training, he returned to Rochester in 1942 to study for an MD.

Like all medical students during the Second World War, Neel was inducted into military service. Rochester was the base for studies in radiation biology associated with the Manhattan Project, and at the end of the war, with Neel still in the military, a chance friendship with the adjutant to the head of the project resulted in Neel's appointment to help organize a genetical survey of the atomic bomb survivors. In 1946-1947, Neel lived in Hiroshima, organizing this project, part of the Atomic Bomb Casualty Committee (ABCC), and he maintained a close connection to the study until his death. His work in Japan mushroomed, too, into a series of related projects into the biology and genetics of consanguinity, among other topics.

While at Rochester, Neel also began to establish a name for himself in other areas of human genetics. As a resident at Rochester's Strong Memorial Hospital, Neel encountered a case of thalassemia, and reading the medical literature, he became convinced that it was a genetic recessive disease. Over a span of five years, he delineated the genetic basis of haemoglobin diseases - first thalassemia, then sickle cell disease - in the process, helping to precipitate the revolution in biochemical genetics of the 1950s through 1970s. Neel's work also encompassed the evolutionary implications for these diseases, implanting balanced polymorphism and heterozygote advantage into the vocabularies of evolutionary biologists. Neel's studies of thalassemia and sickle cell disease were recognized with the receipt of the Lasker Award in 1955.

In the late 1950s, Neel entered into a third major set of projects, turning to extensive field studies in population genetics. Recognizing that the number of human populations isolated from modern medicines and modern technology was rapidly dwindling, Neel embarked on an ambitious genetic survey of the comparatively "primitive" Xavante of Brazil and, later, the Yanomamo of the Brazilian-Venezuelan borderlands. These studies, carried out over the course of more than a decade, and involving even longer spans of laboratory work, constitute the first and most comprehensive studies of human population and breeding structure and genetic diseases among "primitive" peoples. Dr. Neel died in February, 2000.

From the guide to the James V. Neel, papers, ca. 1939-1999, Circa 1939-1999, (American Philosophical Society)

Born in Yugoslavia in 1895, the geneticist Milislav Demerec graduated from the College of Agriculture at Krizevci in 1916, remaining there are as an adjunct at the Experiment Station until 1919. With the war ended, however, Demerec emigrated to the United States and accepted a position in the Department of Plant Breeding at Cornell University. For four years, he worked under R. A. Emerson, studying the genetic basis of such phenotypic traits in maize as variegation and viriscence of seedlings manifesting somatic mosaicism.

In 1923, Demerec left Cornell for Cold Spring Harbor, where his most productive years of research followed. Beginning as a member of the staff of the Department of Genetics of the Carnegie Institution, he was eventually promoted to Director of the Long Island Biological Association Laboratory in 1941, and of Carnegie's Department of Genetics in 1943. A superlative administrator, under Demerec's watch, the Biological Association and Department of Genetics were effectively combined, and Demerec remained in charge of both until his retirement in 1960. His tenure saw the establishment of the important summer meetings at Cold Spring Harbor, out of which grew the courses in bacteriophage and bacterial genetics. From 1941 to 1960, he organized the equally important Symposium in Quantitative Biology and the summer training courses for geneticists. Part of Demerec's legacy is founded as well in his editorial work on the publications stemming from the Symposia, as well as the Drosophila Guide, The Biology of Drosophila, Advances in Genetics, and the Drosophila Information Service . Demerec was active as well in organizing the International Congresses of Genetics from the 7th Congress in Edinburgh, 1938, through the 11th Congress, 1960.

As a researcher at Cold Spring Harbor, Demerec shifted away from plant genetics to attempts to assess factors regulating mutation rates in Drosophila virilis and to assessing mutation rates at different ontogenetic stages. With H. J. Muller in 1918, he had been involved in some of the earliest efforts to determine whether genetic mutations could be artificially induced, and at Cold Spring during the 1930s, he ramped up his program in radiobiology to a large scale, working on x-ray induced mutations in Drosophila melanogaster . During the 1940s, he explored the role of ultraviolet rays and neutrons in mutation, working in conjunction with M. A. Tuve's laboratory in the Dept. of Terrestrial Magnetism at the Carnegie Institution, and he became increasingly interested in variation in spontaneous mutation rates in D. melanogaster . Demerec helped to establish the existence of mutator genes, and his interests in unstable genes led to an exploration of position effects influencing mutation.

The exigencies of the Second World War led Demerec to a third phase in his research, working on the bacteria Escherichia coli and later Staphylococcus aureus and Salmonella typhimurium . Initially, Demerec performed research using penicillin, aureomycin, and streptomycin to examine bacterial mutation and the genetic basis of antibiotic. He carried these interest into the 1950s, branching out into the mutagenic effects of a variety of salts and organic chemicals, with his final projects, conducted with Philip Hartman, involving study of the fine structure and recombination of genes in Salmonella .

Upon reaching the standard age of retirement, Demerec was replaced as Director at Cold Spring by Arthur Chovnick, who offered Demerec room for research only if he agreed to work with Chovnick's group. As a result, Demerec declined, becoming a senior staff member at Brookhaven National Labortory for five years, 1960-1965, where continued to work on problems in mutation and linkage in Salmonella . Having reached the age of mandatory retirement at Brookhaven, Demerec accepted a position as research professor at C. W. Post College of Long Island University, but died of a heart attack before he assumed the post.

From the guide to the Milislav Demerec Papers, 1919-1966, (American Philosophical Society)

Archival Resources
Role Title Holding Repository
referencedIn Schultz, Jack, 1904?-1971. Papers, 1920-1971. American Philosophical Society Library
referencedIn Alexander Hollaender Papers, 1955-1974 American Philosophical Society
referencedIn Lewis, Warren H. (Warren Harmon), 1870-1964. Papers, ca. 1913-1964. American Philosophical Society Library
referencedIn Hollaender, Alexander, 1898-1986. Papers, 1950-1970. American Philosophical Society Library
referencedIn L. C. Dunn Papers, ca. 1920-1974 American Philosophical Society
creatorOf Demerec, M. (Milislav), 1895-1966. Papers, 1919-1966. American Philosophical Society Library
creatorOf James V. Neel, papers, ca. 1939-1999, Circa 1939-1999 American Philosophical Society
referencedIn Genetics Collection, 1884-1971. American Philosophical Society Library
referencedIn Warren H. (Warren Harmon) Lewis papers, ca. 1913-1964, 1913-1964 American Philosophical Society
creatorOf Muller, H. J. (Hermann Joseph), 1890-1967. Papers, 1910-1967. Indiana University
referencedIn Thomas Foxen Anderson Papers, 1928-1989 American Philosophical Society
referencedIn Salvador E. Luria Papers, 1923-1992 American Philosophical Society
creatorOf Milislav Demerec Papers, 1919-1966 American Philosophical Society
referencedIn Curt Stern Papers, 1907-1981 American Philosophical Society
referencedIn Dobzhansky, Theodosius, 1900-1975. Papers, ca. 1917-1975. American Philosophical Society Library
referencedIn Jack Schultz papers, 1920-1971, 1920-1971 American Philosophical Society
referencedIn Joshua Lederberg Papers, 1904-2008 History of Medicine Division. National Library of Medicine
referencedIn Ernst W. Caspari Papers, 1932-1980 American Philosophical Society
referencedIn Dunn, L. C. (Leslie Clarence), 1893-1974. Papers, [ca. 1920]-1974. American Philosophical Society Library
referencedIn Goodale, Hubert Dana, 1879-1968. Papers, ca. 1919-1956. American Philosophical Society Library
referencedIn Caspari, Ernst Wolfgang, 1909- . Papers, 1932-1980. American Philosophical Society Library
creatorOf Genetics Collection, 1884-1971, 1884-1971 American Philosophical Society
referencedIn Hubert Dana Goodale papers, 1901-1965 American Philosophical Society
referencedIn Barbara McClintock Papers, 1927-1991 American Philosophical Society
referencedIn William B. Provine collection of evolutionary biology reprints, 20th century. Division of Rare and Manuscript Collections, Cornell University Library.
referencedIn Davenport, Charles Benedict, 1866-1944. Charles Benedict Davenport papers, 1874-1944. American Philosophical Society Library
referencedIn Anderson, Th. F. (Thomas Foxen), 1911-1991. Papers, 1928-1989. American Philosophical Society Library
referencedIn L. C. Dunn Papers, ca. 1920-1974 American Philosophical Society
referencedIn Hugh Clark Papers., undated, 1947-1998. Archives & Special Collections at the Thomas J. Dodd Center.
referencedIn Stern, Curt, 1902-1981. Papers, [ca. 1920]-1980. American Philosophical Society Library
Role Title Holding Repository
Relation Name
associatedWith American Jersey Cattle Club. corporateBody
associatedWith American Society of Naturalists. corporateBody
associatedWith Anderson, Th. F. (Thomas Foxen), 1911-1991. person
associatedWith Anderson, Thomas Foxen, 1911-1991 person
associatedWith Babcock, E. B. (Ernest Brown), b. 1877 person
associatedWith Babcock, Ernest Brown, 1877-1954. person
associatedWith Bateson, Beatrice. person
associatedWith Bateson, William, 1861-1926 person
associatedWith Blakeslee, Albert Francis, 1874-1954. person
associatedWith Bridges, Calvin B., 1889-1938. person
associatedWith Bronk, Detlev Wulf, 1897-1975. person
associatedWith Buzzati-Traverso, Adriano A. person
associatedWith Carnegie Institution of Washington. corporateBody
associatedWith Caspari, Ernst Wolfgang, 1909- . person
associatedWith Castle, William E. (William Ernest), 1867-1962. person
correspondedWith Clark, Hugh, 1914- person
associatedWith Cold Spring Harbor Laboratory. corporateBody
associatedWith Condon, Edward Uhler, 1902-1974. person
associatedWith Davenport, Charles Benedict, 1866-1944. person
associatedWith Dempster, Everett R., (Everett Ross), 1903- person
associatedWith Dobzhansky, Theodosius, 1900-1975. person
associatedWith Dunn, L. C. (Leslie Clarence), 1893-1974. person
associatedWith Edmonston person
associatedWith Emerson, Rollins, 1873-1947. person
associatedWith Ephrussi, Boris, 1901- person
associatedWith Genetics Society of America. corporateBody
associatedWith Gessling, Donald C person
associatedWith Goldschmidt, Richard, 1878-1958. person
associatedWith Goodale, Hubert Dana, 1879-1968. person
associatedWith Gowen, John Whittemore, 1893-1967 person
associatedWith Haldane, J. B. S. (John Burdon Sanderson), 1892-1964. person
associatedWith Hare, George Harrison person
associatedWith Hollaender, Alexander, 1898-1986. person
associatedWith Lederberg, Joshua person
associatedWith Lewis, Warren H. (Warren Harmon), 1870-1964. person
associatedWith Luria, S. E., (Salvador Edward), 1912-1991 person
associatedWith McClintock, Barbara, 1902-1992 person
associatedWith Medical Press, Inc corporateBody
associatedWith Mendel, Gregor, 1822-1884 person
associatedWith Metz, Charles W., 1889-1975. person
associatedWith Moe, Henry Allen, 1894-1975. person
associatedWith Montgomery, Eugene A person
associatedWith Moriwaka, Dr person
associatedWith Muller, H. J. (Hermann Joseph), 1890-1967. person
associatedWith Neel, James V., (James Van Gundia), 1915-2000 person
correspondedWith Provine, William B. person
associatedWith Schindler, Alois person
associatedWith Schmidt, Louis person
associatedWith Schultz, Jack, 1904?-1971. person
associatedWith Scott, Thomas F person
associatedWith Sonneborn, T. M. (Tracy Morton), 1905-1981. person
associatedWith Stadler, Janice B., 1912- person
associatedWith Stern, Curt, 1902-1981. person
associatedWith Sunden Photo corporateBody
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associatedWith Timoféeff-Ressovsky, N. W. person
associatedWith Timofeev-Resovskiĭ, N. V., (Nikolaĭ Vladimirovich), 1900-1981 person
associatedWith Umaersus, Magnhild person
associatedWith Urey, Harold Clayton, 1893-1981. person
associatedWith Virtanen, A. I., (Artturi Ilmari), 1895-1973 person
associatedWith Wood, Howard M person
Place Name Admin Code Country
Subject
Human population genetics
Indians of South America--Brazil
Penicillin
Heredity
Environmental health
Radiation--Physiological effect
Amerindians
Mutagens
Biology--Research
Radiogenetics
Mutation (Biology)
Cattle--Breeding
Genetics--Research
Atmospheric radiation
Drosophila virilis
Longevity--Genetic aspects
Drosophila--Genetics
Xavante Indians
Chemical mutagenesis
Plant genetics
Breeding
Indians of South America--Venezuela
Yanomamo Indians
Political refugees
Hematology
Antibiotics
Maize Genetics
Consanguinity
Occupation
Activity

Person

Birth 1895-01-11

Death 1966-04-12

Male

Americans

English

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