John Hepburn [sometimes "Hepbourne"] (circa 1714-circa 1780) was a merchant born in Prince George's County, Maryland, the only child of Dr. Patrick Hepburn (died circa 1726) and an unknown first wife. He married Mary Chew (circa 1714-circa 1770) of Anne Arundel County. John and Mary Hepburn had three children: Samuel Chew Hepburn (circa 1759-circa 1806); Ann Hepburn (birth and death dates unknown); and John Hepburn, Jr. (died circa 1774).
Samuel Chew Hepburn married Jean Muir (1759-circa 1810) of Dorchester County, Maryland sometime before 1780. They had four children: Mary "Polly" Hepburn (circa 1780-circa 1849); John Muir Hepburn (1790-1850); Sarah Hepburn (birth and death unknown); and Patricus Hepburn (birth and death unknown).
From the guide to the Hepburn Family papers, 1739-1813, 1748-1795, (State of Maryland and Historical Collections)