Constellation Similarity Assertions

Dr. Louis Sokoloff spent most of his career as a neurochemical researcher with the National Institute of Mental Health (NIMH). From 1957 until his retirement more than 40 years later, he served as Chief of the Section (later Laboratory) of Cerebral Metabolism. In 1981 he won the Albert Lasker Award for Clinical Research for developing methods of visualizing biochemical activity in neural pathways that led to development of positron-emission tomography (PET).

Louis Sokoloff was born in Philadelphia in 1921. He earned the B.A., M.A., and M.D. degrees at the University of Pennsylvania. Influenced by Lewis V. Heilbrunn and other faculty, he decided on a career in scientific research, more specifically mammalian physiology and biochemistry. His experiences during a medical internship at Philadelphia Medical Hospital and on active duty in the Army Medical Corps at Camp Lee, Va., from 1946 to 1949, fostered an interest in physiological and biochemical mechanisms of the brain in mental disease. In 1949 he began grant-funded research at the University of Pennsylvania under former instructor and neuroscientist, Dr. Seymour S. Kety. During his four years there his primary research projects were studies of peripheral circulation, and, with Benton King and Richard Wechsler, the effects of epinephrine and norephinephrine and epinephrine on cerebral blood flow (CBF) and cerebral 02 consumption (MCR02).

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