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Dorothy Swaine Thomas was born on 24 October 1899 in Baltimore, Maryland, the daughter of John Knight and Sarah (Swaine) Thomas. She received her B.A. degree from Barnard College in 1922 and also earned a Ph. D. in 1924 from the University of London School of Economics where she was a recipient of the Hutchinson Research Medal. Between the years of 1924 and 1948, she held research and/or academic appointments at the University of California at Berkeley, Yale University, Columbia Teachers College, the Carnegie Corporation, the Social Science Research Council, the Social Science Institute at the University of Stockholm, and the Federal Reserve Bank in New York.

Dr. Thomas arrived on the faculty of the Wharton School of the University of Pennsylvania in 1948 as a research professor of sociology and incidentally was the first female professor in the Wharton School. While at the University, she was a co-director of the Study of Population Redistribution and Economic Growth from 1952 to 1959, research director of the Population Studies Center from 1959 to 1970, and co-director of Population Studies Center from 1964 to 1970.

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