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C. F. Dight was born in Mercer, Pennsylvania in 1856. He graduated with a medical degree from the University of Michigan in 1879. After serving as a health officer in Holton, Michigan, from 1879 to 1881 he returned to the university to assist pathology professor Alonzo B. Palmer. From 1883 to 1889 he was professor of anatomy and physiology at the American University of Beirut, Syria (now Lebanon). From about 1890 to 1892 Dight served as resident physician and teacher of physiology and hygiene at Shattuck School, Faribault, Minnesota.

Dight married Dr. Mary A. Crawford in 1892, but was divorced in 1899 without children. During this period he practiced medicine for a year in Portsmouth, New Hampshire; taught for two years as professor at the medical school of New Orleans University; and spent four years in travel and study in New York, Chicago, Ann Arbor, and the University of Pennsylvania.

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