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Pediatrician and sickle cell anemia expert Dr. Charles Francis Whitten was born on February 2, 1922 in Wilmington, Delaware to school teachers Emma Clorinda Carr Whitten and Tobias Emmanuel Whitten. He grew up on Wilmington's East Side next door to future jazz trumpeter Clifford Brown. Whitten attended Number 5 Elementary School and graduated fourth in his class from Howard High School in 1940. In 1942, he earned his B.S. degree in zoology from the University of Pennsylvania. Whitten then studied medicine at Meharry Medical College in Nashville, Tennessee and earned his M.D. degree in 1945 at age twenty-three.

After his internship at Harlem Hospital, Whitten worked as a general practitioner in Lackawanna, New York from 1946 to 1951.Whitten then served two years as a captain in the United States Medical Corps before returning to the University of Pennsylvania's Graduate School of Medicine for a year of advanced study in pediatrics. In 1953, Whitten began a two-year residency in pediatrics at Children's Hospital in Buffalo, New York. In 1955, he moved to Detroit, Michigan for a one year fellowship to study pediatric hematology under Dr. Wolf Zeltzer. Whitten became the first and only African American to head a department in a Detroit hospital when he was selected clinical director of pediatrics at Detroit Receiving Hospital in 1956. Whitten worked as an attending pediatrician at Children's Hospital of Michigan from 1962 to 1999. He started teaching medicine as an instructor in pediatrics at Wayne State University in 1956. Whitten was named assistant professor in 1959, served as full professor of pediatrics from 1970 to 1990, and became associate dean of curricular affairs in 1976 and of special programs in 1992.

Whitten joined Dr. Charles Wright in establishing the African Medical Education Fund in 1960. In 1969, Whitten instituted Wayne State University's Post Baccalaureate Enrichment Program to better prepare black students for medical school. In 1971, Whitten with Dorothy Boswell spearheaded the National Association for Sickle Cell Disease, now the Sickle Cell Disease Association of America. He also formed the Sickle Cell Detection and Information Center. Whitten became program director for the Comprehensive Sickle Cell Center at Wayne State University in 1973. In 2002, Whitten was named Michiganian of the Year, and in 2004, was named distinguished professor of pediatrics, emeritus at Wayne State University.

Whitten passed away on August 14, 2008 at the age of 86. He is survived by his wife, Eloise Culmer Whitten, an expert on pre-school reading. Together, they supported a number of worthy causes, including a clinic in Haiti.

Whitten was interviewed by The HistoryMakers on March 8, 2007.

Charles F. Whitten was born on February 2, 1922 in Wilmington, Delaware. He left his home town after high school to attend the University of Pennsylvania, where he graduated with a degree in zoology in 1942. He received his medical training at Meharry Medical College in Nashville, graduating in 1945. Dr. Whitten practiced general medicine in Lackawanna, New York for several years before choosing to specialize in pediatric hematology. After receiving advanced training at the University of Pennsylvania Medical School and the Children's Hospital at Buffalo, New York, he moved to Detroit in 1957 where he undertook the dual roles of professor at Wayne State School of Medicine and pediatrician at Detroit Receiving Hospital.

Dr. Whitten's contributions to medical education at Wayne State include the founding of the African Medical Education Fund in 1960, which provided financial assistance for African American Medical students who agreed to serve a specified post-graduate period practicing in Africa, and a post baccalaureate program that enabled non-accepted black applicants an opportunity to enter medical school. His distinguished work at the Detroit Receiving Hospital earned him the position of chief of pediatrics, a first for a black physician in Detroit. Throughout his career, Dr. Whitten's primary research centered on sickle cell anemia. He published several studies and worked to expand awareness and promote education about the disease. Dr. Whitten was instrumental in the foundation, in 1971, of the National Association for Sickle Cell Disease as well as the opening of the Comprehensive Sickle Cell Center at Wayne State the same year. He remained professionally active well into his seventh decade. Charles Whitten died August 14, 2008 at the age of 86.