Guo, originally named Guo Kaizhen, was born on November 10 or 16, in the small town of Shawan, located on the Dadu River some 40 km (25 mi) southwest from what was then called the city of Jiading (Lu) (Chia-ting (Lu), 嘉定(路)), and now is the central urban area of the prefecture level city of Leshan in Sichuan Province.
Along with holding important government offices in the People's Republic of China, Guo was a prolific writer, not just of poetry but also fiction, plays, autobiographies, translations, and historical and philosophical treatises. He was the first President of the Chinese Academy of Sciences and remained so from its founding in 1949 until his death in 1978. He was also the first president of University of Science & Technology of China (USTC), a new type of university established by the Chinese Academy of Sciences (CAS) after the founding of the People's Republic of China and aimed at fostering high-level personnel in the fields of science and technology.
For the first 15 years of the PRC, Guo, with his extensive knowledge of Chinese history and culture, was the ultimate arbiter of philosophical matters relating to art, education, and literature, although all of his most vital and important work had been written before 1949.